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Heather Key Tiller's Filigree (Charleston)

(Fortune Small Business) -- Entrepreneurial spirit and parental advice don't always jibe, but sometimes mother does know best. It was Heather Key Tiller's mom, Susan Foxworth, who in 2001 noticed the FOR RENT sign on an empty store at 47 John St. as the two left a nearby French restaurant. At the time, Tiller worked as an office manager at a local jewelry store while also designing her own pieces at home and selling them on a wobbly card table at the Saturday farmers' market in downtown Charleston.

Read full story: CNNmoney: Selling jewelry in chic Charleston